Protein Markers of Disease, Drug Efficacy and Toxicity, and their Use in Pharmaceutical Discovery and Development: A Review of Selected Published Applications
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چکیده
Virtually all pharmaceutically-relevant biological mechanisms can be monitored quantitatively using specific protein markers in samples of serum, urine, or tissue. The value of effective biological markers is substantial, allowing carly dctcction and classification of toxicities, ranking of potential lead compounds, acceleration of clinical trials. and stratification of patients into the most responsive groups. Nevertheless, few such markers are in current use in fact few have so far been discovered. Pharmaceutical proteomics addresses this need through systematic discovery, characterization and validation of novel tissue and body fluid protein markers .
منابع مشابه
Pharmaceutical Advances and Proteomics Researches
Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...
متن کاملPharmaceutical Advances and Proteomics Researches
Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...
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